دانلود رایگان مجموعه مقالات علمی اشپرینگر در زمینه منطق فازی — بخش سی و هشتم
منطق فازی (Fuzzy Logic) اولین بار در پی تنظیم نظریه مجموعه‌های فازی به وسیله پروفسور لطفی زاده (۱۹۶۵ میلادی) در صحنه محاسبات نو ظاهر شد. در واقع منطق فازی از منطق ارزش‌های «صفر و یک» نرم‌افزارهای کلاسیک فراتر رفته و درگاهی جدید برای دنیای علوم نرم‌افزاری و رایانه‌ها می‌گشاید، زیرا فضای شناور و نامحدود بین اعداد صفر و یک را نیز در منطق و استدلال‌های خود به کار می‌گیرد. در ادامه مقالات علمی انتشارات بین المللی اشپرینگر (Springer) در زمینه منطق فازی (Fuzzy Logic) برای دانلود آمده است. می توانید برای دانلود هر یک از مقالات از سرور دانلود متلب سایت، بر روی لینک دانلود هر یک از آن ها، کلیک کنید.
این نوشته حاوی بخشی از مجموعه کامل مقالات است. برای دریافت سایر بخش ها، به لینک زیر مراجعه نمایید:
دانلود رایگان مجموعه مقالات علمی اشپرینگر در زمینه منطق فازی — فهرست اصلی
| عنوان اصلی مقاله | Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Matthew J Kraeutler, Anthony R Soltis, Jeffrey J Saucerman |
| چکیده / توضیح | New approaches are needed for large-scale predictive modeling of cellular signaling networks. While mass action and enzyme kinetic approaches require extensive biochemical data, current logic-based approaches are used primarily for qualitative predictions and have lacked direct quantitative comparison with biochemical models. |
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| عنوان اصلی مقاله | The role of noise and positive feedback in the onset of autosomal dominant diseases |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | William J Bosl, Rong Li |
| چکیده / توضیح | Autosomal dominant (AD) diseases result when a single mutant or non-functioning gene is present on an autosomal chromosome. These diseases often do not emerge at birth. There are presently two prevailing theories explaining the expression of AD diseases. One explanation originates from the Knudson two-hit theory of hereditary cancers, where loss of heterozygosity or occurrence of somatic mutations impairs the function of the wild-type copy. While these somatic second hits may be sufficient for stable disease states, it is often difficult to determine if their occurrence necessarily marks the initiation of disease progression. A more direct consequence of a heterozygous genetic background is haploinsufficiency, referring to a lack of sufficient gene function due to reduced wild-type gene copy number; however, haploinsufficiency can involve a variety of additional mechanisms, such as noise in gene expression or protein levels, injury and second hit mutations in other genes. In this study, we explore the possible contribution to the onset of autosomal dominant diseases from intrinsic factors, such as those determined by the structure of the molecular networks governing normal cellular physiology. |
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| عنوان اصلی مقاله | DENSE: efficient and prior knowledge-driven discovery of phenotype-associated protein functional modules |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Willam Hendrix, Andrea M Rocha, Kanchana Padmanabhan, Alok Choudhary, Kathleen Scott, James R Mihelcic, Nagiza F Samatova |
| چکیده / توضیح | Identifying cellular subsystems that are involved in the expression of a target phenotype has been a very active research area for the past several years. In this paper, cellular subsystem refers to a group of genes (or proteins) that interact and carry out a common function in the cell. Most studies identify genes associated with a phenotype on the basis of some statistical bias, others have extended these statistical methods to analyze functional modules and biological pathways for phenotype-relatedness. However, a biologist might often have a specific question in mind while performing such analysis and most of the resulting subsystems obtained by the existing methods might be largely irrelevant to the question in hand. Arguably, it would be valuable to incorporate biologist's knowledge about the phenotype into the algorithm. This way, it is anticipated that the resulting subsytems would not only be related to the target phenotype but also contain information that the biologist is likely to be interested in. |
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| عنوان اصلی مقاله | Gene Ontology Function prediction in Mollicutes using Protein-Protein Association Networks |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Antonio Gómez, Juan Cedano, Isaac Amela, Antoni Planas, Jaume Piñol, Enrique Querol |
| چکیده / توضیح | Many complex systems can be represented and analysed as networks. The recent availability of large-scale datasets, has made it possible to elucidate some of the organisational principles and rules that govern their function, robustness and evolution. However, one of the main limitations in using protein-protein interactions for function prediction is the availability of interaction data, especially for Mollicutes. If we could harness predicted interactions, such as those from a Protein-Protein Association Networks (PPAN), combining several protein-protein network function-inference methods with semantic similarity calculations, the use of protein-protein interactions for functional inference in this species would become more potentially useful. |
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| عنوان اصلی مقاله | CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Camille Terfve, Thomas Cokelaer, David Henriques, Aidan MacNamara, Emanuel Goncalves, Melody K Morris, Martijn van Iersel, Douglas A Lauffenburger, Julio Saez-Rodriguez |
| چکیده / توضیح | Cells process signals using complex and dynamic networks. Studying how this is performed in a context and cell type specific way is essential to understand signaling both in physiological and diseased situations. Context-specific medium/high throughput proteomic data measured upon perturbation is now relatively easy to obtain but formalisms that can take advantage of these features to build models of signaling are still comparatively scarce. |
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| عنوان اصلی مقاله | SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Claudine Chaouiya, Duncan Bérenguier, Sarah M Keating, Aurélien Naldi, Martijn P van Iersel, Nicolas Rodriguez, Andreas Dräger, Finja Büchel, Thomas Cokelaer, Bryan Kowal, Benjamin Wicks, Emanuel Gonçalves, Julien Dorier, Michel Page, Pedro T Monteiro, Axel von Kamp, Ioannis Xenarios, Hidde de Jong, Michael Hucka, Steffen Klamt, Denis Thieffry, Nicolas Le Novère, Julio Saez-Rodriguez, Tomáš Helikar |
| چکیده / توضیح | Qualitative frameworks, especially those based on the logical discrete formalism, are increasingly used to model regulatory and signalling networks. A major advantage of these frameworks is that they do not require precise quantitative data, and that they are well-suited for studies of large networks. While numerous groups have developed specific computational tools that provide original methods to analyse qualitative models, a standard format to exchange qualitative models has been missing. |
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| عنوان اصلی مقاله | Predicting toxicity through computers: a changing world |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Emilio Benfenati |
| چکیده / توضیح | The computational approaches used to predict toxicity are evolving rapidly, a process hastened on by the emergence of new ways of describing chemical information. Although this trend offers many opportunities, new regulations, such as the European Community's 'Registration, Evaluation, Authorisation and Restriction of Chemicals' (REACH), demand that models be ever more robust. |
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| عنوان اصلی مقاله | 2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Freek G Bouwman, Baukje de Roos, Isabel Rubio-Aliaga, L Katie Crosley, Susan J Duthie, Claus Mayer, Graham Horgan, Abigael C Polley, Carolin Heim, Susan LM Coort, Chris T Evelo, Francis Mulholland, Ian T Johnson, Ruan M Elliott, Hannelore Daniel, Edwin CM Mariman |
| چکیده / توضیح | Proteomic technologies applied for profiling human biofluids and blood cells are considered to reveal new biomarkers of exposure or provide insights into novel mechanisms of adaptation. |
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| عنوان اصلی مقاله | Logic minimization and rule extraction for identification of functional sites in molecular sequences |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Raul Cruz-Cano, Mei-Ling Ting Lee, Ming-Ying Leung |
| چکیده / توضیح | Logic minimization is the application of algebraic axioms to a binary dataset with the purpose of reducing the number of digital variables and/or rules needed to express it. Although logic minimization techniques have been applied to bioinformatics datasets before, they have not been used in classification and rule discovery problems. In this paper, we propose a method based on logic minimization to extract predictive rules for two bioinformatics problems involving the identification of functional sites in molecular sequences: transcription factor binding sites (TFBS) in DNA and O-glycosylation sites in proteins. TFBS are important in various developmental processes and glycosylation is a posttranslational modification critical to protein functions. |
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| عنوان اصلی مقاله | Collaborative development of predictive toxicology applications |
| نوع مقاله | مقاله ژورنال |
| نویسندگان | Barry Hardy, Nicki Douglas, Christoph Helma, Micha Rautenberg, Nina Jeliazkova, Vedrin Jeliazkov, Ivelina Nikolova, Romualdo Benigni, Olga Tcheremenskaia, Stefan Kramer, Tobias Girschick, Fabian Buchwald, Joerg Wicker, Andreas Karwath, Martin Gütlein, Andreas Maunz, Haralambos Sarimveis, Georgia Melagraki, Antreas Afantitis, Pantelis Sopasakis, David Gallagher, Vladimir Poroikov, Dmitry Filimonov, Alexey Zakharov, Alexey Lagunin, Tatyana Gloriozova, Sergey Novikov, Natalia Skvortsova, Dmitry Druzhilovsky, Sunil Chawla, Indira Ghosh, Surajit Ray, Hitesh Patel, Sylvia Escher |
| چکیده / توضیح | OpenTox provides an interoperable, standards-based Framework for the support of predictive toxicology data management, algorithms, modelling, validation and reporting. It is relevant to satisfying the chemical safety assessment requirements of the REACH legislation as it supports access to experimental data, (Quantitative) Structure-Activity Relationship models, and toxicological information through an integrating platform that adheres to regulatory requirements and OECD validation principles. Initial research defined the essential components of the Framework including the approach to data access, schema and management, use of controlled vocabularies and ontologies, architecture, web service and communications protocols, and selection and integration of algorithms for predictive modelling. OpenTox provides end-user oriented tools to non-computational specialists, risk assessors, and toxicological experts in addition to Application Programming Interfaces (APIs) for developers of new applications. OpenTox actively supports public standards for data representation, interfaces, vocabularies and ontologies, Open Source approaches to core platform components, and community-based collaboration approaches, so as to progress system interoperability goals. |
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